Mammary ductoscopy: past, present, future

Mammary ductoscopy is a powerful modality with enormous potential to help improve patient care through enhancing the diagnosis and treatment of patients with breast disease. The ability to see ductal pathology and monitor response to therapy real time has enormous potential to expand our understanding of disease processes. Technological improvements involving optics, scope design, ductal access and interventional ductoscopy becoming feasible will help move this field forward. Historical developments, current applications, personal experience, and future directions will be discussed

Increased serum levels of TGFβ1 in children with localized scleroderma

scleroderm

Specific staining of human chromosomes in Chinese hamster x man hybrid cell lines demonstrates interphase chromosome territories

In spite of Carl Rabl's (1885) and Theodor Boveri's (1909) early hypothesis that chromosomes occupy discrete territories or domains within the interphase nucleus, evidence in favor pf this hypothesis has been limited and indirect so far in higher plants and animals. The alternative possibility that the chromatin fiber of single chromosomes might be extended throughout the major part of even the whole interphase nucleus has been considered for many years. In the latter case, chromosomes would only exist as discrete chromatin bodies during mitosis but not during interphase. Both possibilities are compatible with Boveri's well established paradigm of chromosome individuality. Here we show that an active human X chromosome contained as the only human chromosome in a Chinese hamster x man hybrid cell line can be visualized both in metaphse plates and in interphase nuclei after in situ hybridization with either 3H- or biotin-labeled human genomic DNA. We demonstrate that this chromosome is organized as a distinct chromatin body throughout interphase. In addition, evidence for the territorial organization of human chromosomes is also presented for another hybrid cell line containing several autosomes and the human X chromosome. These findings are discussed in the context of our present knowledge of the organization and topography of interphase chromosomes. General applications of a strategy aimed at specific staining of individual chromosomes in experimental and clinical cytogenetics are briefly considered

Toward High-Precision Measures of Large-Scale Structure

I review some results of estimation of the power spectrum of density fluctuations from galaxy redshift surveys and discuss advances that may be possible with the Sloan Digital Sky Survey. I then examine the realities of power spectrum estimation in the presence of Galactic extinction, photometric errors, galaxy evolution, clustering evolution, and uncertainty about the background cosmology.Comment: 24 pages, including 11 postscript figures. Uses crckapb.sty (included in submission). To appear in ``Ringberg Workshop on Large-Scale Structure,'' ed D. Hamilton (Kluwer, Amsterdam), p. 39

Parenting gifted and talented children: What are the key child behaviour and parenting issues?

Objective: The literature on gifted and talented children is limited. Little is known about the types and nature of difficulties experienced by gifted and talented children, and even less known about parenting issues related to parenting a gifted and talented child. The aim of the present study was to describe children's behavioural and emotional adjustment, and the factors that contribute to children's difficulties, as well as to examine the styles of discipline used by parents of gifted and talented children and their level of confidence in managing specific parenting tasks

Determination of Pericardial Adipose Tissue Increases the Prognostic Accuracy of Coronary Artery Calcification for Future Cardiovascular Events

Objectives: Pericardial adipose tissue (PAT) is associated with coronary artery plaque accumulation and the incidence of coronary heart disease. We evaluated the possible incremental prognostic value of PAT for future cardiovascular events. Methods: 145 patients (94 males, age 60 10 years) with stable coronary artery disease underwent coronary artery calcification (CAC) scanning in a multislice CT scanner, and the volume of pericardial fat was measured. Mean observation time was 5.4 years. Results: 34 patients experienced a severe cardiac event. They had a significantly higher CAC score (1,708 +/- 2,269 vs. 538 +/- 1,150, p 400, 3.5 (1.9-5.4; p = 0.007) for scores > 800 and 5.9 (3.7-7.8; p = 0.005) for scores > 1,600. When additionally a PAT volume > 200 cm(3) was determined, there was a significant increase in the event rate and relative risk. We calculated a relative risk of 2.9 (1.9-4.2; p = 0.01) for scores > 400, 4.0 (2.1-5.0; p = 0.006) for scores > 800 and 7.1 (4.1-10.2; p = 0.005) for scores > 1,600. Conclusions:The additional determination of PAT increases the predictive power of CAC for future cardiovascular events. PAT might therefore be used as a further parameter for risk stratification. Copyright (C) 2012 S. Karger AG, Base

Intelligent opinion mining and sentiment analysis using artificial neural networks

The article formulates a rigorously developed concept of opinion mining and sentiment analysis using hybrid neural networks. This conceptual method for processing natural-language text enables a variety of analyses of the subjective content of texts. It is a methodology based on hybrid neural networks for detecting subjective content and potential opinions, as well as a method which allows us to classify different opinion type and sentiment score classes. Moreover, a general processing scheme, using neural networks, for sentiment and opinion analysis has been presented. Furthermore, a methodology which allows us to determine sentiment regression has been devised. The paper proposes a method for classification of the text being examined based on the amount of positive, neutral or negative opinion it contains. The research presented here offers the possibility of motivating and inspiring further development of the methods that have been elaborated in this paper.Stuart, KDC.; Majewski, M. (2015). Intelligent opinion mining and sentiment analysis using artificial neural networks. Lecture Notes in Computer Science. 9492:103-110. doi:10.1007/978-3-319-26561-2_13S1031109492Feldman, R.: Techniques and applications for sentiment analysis. Commun. ACM 56(4), 82–89 (2013)Taboada, M., Brooke, J., Tofiloski, M., Voll, K., Stede, M.: Lexicon-based methods for sentiment analysis. Comput. Linguist. 37(2), 267–307 (2011)Mohammad, S.M., Turney, P.D.: Crowdsourcing a word-emotion association lexicon. Comput. Intell. 29(3), 436–465 (2013)Chen, H., Zimbra, D.: AI and opinion mining. IEEE Intell. Syst. 25(3), 74–80 (2010)Majewski, M., Zurada, J.M.: Sentence recognition using artificial neural networks. Knowl. Based Syst. 21(7), 629–635 (2008)Kacalak, W., Stuart, K.D., Majewski, M.: Intelligent natural language processing. In: Jiao, L., Wang, L., Gao, X., Liu, J., Wu, F. (eds.) ICNC 2006. LNCS, vol. 4221, pp. 584–587. Springer, Heidelberg (2006)Kacalak, W., Stuart, K., Majewski, M.: Selected problems of intelligent handwriting recognition. In: Melin, P., Castillo, O., Ramírez, E.G., Kacprzyk, J., Pedrycz, W. (eds.) IFSA 2007. Advances in Soft Computing, vol. 41, pp. 298–305. Springer, Cancun (2007)Stuart, K.D., Majewski, M.: Selected problems of knowledge discovery using artificial neural networks. In: Liu, D., Fei, S., Hou, Z., Zhang, H., Sun, C. (eds.) ISNN 2007, Part III. LNCS, vol. 4493, pp. 1049–1057. Springer, Heidelberg (2007)Stuart, K., Majewski, M.: A new method for intelligent knowledge discovery. In: Castillo, O., Melin, P., Ross, O.M., Cruz, R.S., Pedrycz, W., Kacprzyk, J. (eds.) IFSA 2007. Advances in Soft Computing, vol. 42, pp. 721–729. Springer, Heidelberg (2007)Stuart, K.D., Majewski, M.: Artificial creativity in linguistics using evolvable fuzzy neural networks. In: Hornby, G.S., Sekanina, L., Haddow, P.C. (eds.) ICES 2008. LNCS, vol. 5216, pp. 437–442. Springer, Heidelberg (2008)Stuart, K.D., Majewski, M.: Evolvable neuro-fuzzy system for artificial creativity in linguistics. In: Huang, D.-S., Wunsch II, D.C., Levine, D.S., Jo, K.-H. (eds.) ICIC 2008. LNCS (LNAI), vol. 5227, pp. 46–53. Springer, Heidelberg (2008)Stuart, K.D., Majewski, M., Trelis, A.B.: Selected problems of intelligent corpus analysis through probabilistic neural networks. In: Zhang, L., Lu, B.-L., Kwok, J. (eds.) ISNN 2010, Part II. LNCS, vol. 6064, pp. 268–275. Springer, Heidelberg (2010)Stuart, K.D., Majewski, M., Trelis, A.B.: Intelligent semantic-based system for corpus analysis through hybrid probabilistic neural networks. In: Liu, D., Zhang, H., Polycarpou, M., Alippi, C., He, H. (eds.) ISNN 2011, Part I. LNCS, vol. 6675, pp. 83–92. Springer, Heidelberg (2011)Specht, D.F.: Probabilistic neural networks. Neural Netw. 3(1), 109–118 (1990)Specht, D.F.: A general regression neural network. IEEE Trans. Neural Netw. 2(6), 568–576 (1991